反应详情

温度

150 °C

A mixture of 4.6 g (27 mmol) N-(2-chloropyridin-4-yl)acetamide (commercially available) and 5.2 g (41 mmol) 1-(2-propyl-)-piperazine in 2 ml DMF was heated to 150° C. for 4 h. Purification of the crude mixture with flash column chromatography on silica eluting with a gradient formed from DCM (1% NEt3) and methanol yielded after evaporation of the product fractions 3.38 g (47%) of the title compound as white solid. MS: (m/e): 263.4 (MH+).

1. customPurification of the crude mixture with flash column chromatography on silica eluting with a gradient
2. customformed from DCM (1% NEt3) and methanol
3. customyielded
4. customafter evaporation of the product fractions 3.38 g (47%) of the title compound as white solid