反应详情

温度

100 °C

A mixture of 2.1 g (8 mmol) N-[2-(4-isopropyl-piperazin-1-yl)-pyridin-4-yl]-acetamide and 10.5 ml 4N HCl in 25 ml dioxane was heated to 100° C. for 2 h. After evaporation of all volatiles the residue was treated with water and NaHCO3 aq. sat. and extracted with DCM. The combined organic layers were washed with NaCl aq. sat., dried with MgSO4 and evaporated. The residue was triturated with DCM and dried to yield 1 g (57%) of the title compounds as white solid. MS: (m/e): 221.3 (MH+).

1. customAfter evaporation of all volatiles the residue
2. additionwas treated with water and NaHCO3 aq. sat.
3. extractionextracted with DCM
4. washThe combined organic layers were washed with NaCl aq. sat.
5. dry with materialdried with MgSO4
6. customevaporated
7. customThe residue was triturated with DCM
8. customdried