Hydrochloric Acid → [2-(4-Isopropyl-piperazin-1-yl)-pyridin-4-yl]-methyl-amine hydrochloride

HRID 272540Notes

Reaction equation

HRID 272540 reaction equation
[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[C:14]([N:16](C)[C:17](=O)C)[CH:13]=[CH:12][N:11]=2)[CH2:6][CH2:5]1)([CH3:3])[CH3:2].[ClH:21]>O.O1CCOCC1>[ClH:21].[CH:1]([N:4]1[CH2:5][CH2:6][N:7]([C:10]2[CH:15]=[C:14]([NH:16][CH3:17])[CH:13]=[CH:12][N:11]=2)[CH2:8][CH2:9]1)([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68941905N-[2-(4-Isopropyl-piperazin-1-yl)-pyridin-4-yl]-N-methyl-acetamide

Product 1

HCID 68942815[2-(4-Isopropyl-piperazin-1-yl)-pyridin-4-yl]-methyl-amine hydrochlorideYield 76%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

A mixture of 2.5 g (9 mmol) N-[2-(4-isopropyl-piperazin-1-yl)-pyridin-4-yl]-N-methyl-acetamide and 10 ml 4N HCl in 5 ml water and 25 ml dioxane was stirred at room temperature. After evaporation of the volatiles the residue was triturated with a mixture formed from acetone and dioxane and dried under vacuum to yield 1.8 g (76%) of the title compound (intermediate 11) as light red solid. MS: (m/e): 235.2 (MH+).

Workup

  1. customAfter evaporation of the volatiles the residue
  2. customwas triturated with a mixture
  3. customformed from acetone and dioxane
  4. customdried under vacuum

Sources & evidence

ORD record
ord-5f7a81d72e3a4a5facd4c96652a14727
Source dataset
uspto-grants-2008_11
Patent number
US07456175B2

Reaction notes

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