反应详情

温度

85 °C

To a suspension of bromomethyl cyclopropane (4 mmol) and 4-piperidone hydrate hydrochloride (4 mmol) in acetonitrile (30 mL) was added sodium carbonate (11 mmol). The reaction mixture was stirred 16 h at 85° C. The resulting suspension was filtered and the solid was washed with acetonitrile. The filtrate was concentrated in vacuo and purified by column chromatography on silica eluting with DCM/2N NH3 in methanol 97:3 to yield 339 mg of the title compound as yellow oil. MS (m/e): 154.2 (MH+, 100%).

1. filtrationThe resulting suspension was filtered
2. washthe solid was washed with acetonitrile
3. concentrationThe filtrate was concentrated in vacuo
4. custompurified by column chromatography on silica eluting with DCM/2N NH3 in methanol 97:3