HCID 58959693, compound → HCID 58959701, compound

HRID 272568Notes

Reaction equation

HRID 272568 reaction equation
C[O:2][C:3]([C:5]1[C:6]2[C:7](=[O:21])[CH:8]=[C:9]([C:16]([O:18]CC)=[O:17])[NH:10][C:11]=2[C:12]([F:15])=[CH:13][CH:14]=1)=[O:4]>Cl>[F:15][C:12]1[C:11]2[NH:10][C:9]([C:16]([OH:18])=[O:17])=[CH:8][C:7](=[O:21])[C:6]=2[C:5]([C:3]([OH:4])=[O:2])=[CH:14][CH:13]=1

Participants

3

Reactant 1

HCID 58959693HCID 58959693, compound

Product 1

HCID 58959701HCID 58959701, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
100 °C

Procedure

To a 2 N aqueous HCl (200 mL) solution was added 34 (10.0 g, 34.1 mmol). The reaction mixture was heated at 100° C. for 18 h and then cooled to room temperature. The resulting precipitate was filtered and dried under vacuum at 60° C. for 18 h to afford an off-white solid (35, 8.11 g, 94.7%). 1H NMR (DMSO-d6, 300 MHz) δ ?7.65 (t, J=8.2, 1H), 7.39-7.43 (m, 1H), 6.93 (s, 1H).

Workup

  1. temperaturecooled to room temperature
  2. filtrationThe resulting precipitate was filtered
  3. customdried under vacuum at 60° C. for 18 h
  4. customto afford an off-white solid (35, 8.11 g, 94.7%)

Sources & evidence

ORD record
ord-8d52047dd96b476d93df148e8151993e
Source dataset
uspto-grants-2008_11
Patent number
US07456178B2

Reaction notes

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