反应详情

Compound (1G) (250 mg, 0.85 mmol) and 2-amino-2-ethyl-1,3-propanediol (298 mg, 2.5 mmol) in NMP (0.25 mL) were stirred at 120° C. for 4 h. After cooling to room temperature, the reaction mixture was poured into water and extracted with EtOAc (2×25 mL). The combined organic layers were dried over sodium sulfate and evaporated in vacuo. The crude product was purified by chromatography (silica gel, CH2Cl2:MeOH, 95:5) to afford 150 mg of the above-titled compound (Example 1). Mp=110-112.9° C. MW (M+H)+=376.

1. extractionextracted with EtOAc (2×25 mL)
2. dry with materialThe combined organic layers were dried over sodium sulfate
3. customevaporated in vacuo
4. customThe crude product was purified by chromatography (silica gel, CH2Cl2:MeOH, 95:5)