反应详情

DL-2-[3-(Acetylthio)-1-oxopropyl]-5-oxo-3-pyrazolidinecarboxylic acid (1.2 g) is treated in an argon atmosphere with 8 ml of a cold solution of 6.5 N ammonium hydroxide. After one hour at room temperature, the solution is extracted with ethyl acetate and treated with concentrated hydrochloric acid to pH 2. The water soluble product is extracted with five 20 ml portions of ethyl acetate. The combined extracts are dried over magnesium sulfate and evaporated to an oil which gradually solidifies. This material is dried in vacuo at 100° C. for 1 hour yielding 0.45 g of the title compound, melting point 140°-142° C.

1. extractionthe solution is extracted with ethyl acetate
2. additiontreated with concentrated hydrochloric acid to pH 2
3. extractionThe water soluble product is extracted with five 20 ml portions of ethyl acetate
4. dry with materialThe combined extracts are dried over magnesium sulfate
5. customevaporated to an oil which
6. customThis material is dried in vacuo at 100° C. for 1 hour