反应详情

A solution of 11.8 g (52.0 mmol) of 5-Bromo-2,4-dichloropyrimidine in 10 ml of acetonitrile at 0° C. is mixed with 4.73 ml (52.0 mmol) of aniline. The batch is stirred for 3 days at room temperature and finally concentrated by evaporation. The remaining residue is purified by chromatography (hexane/ethyl acetate: 3:1 plus 1% triethylamine). 4.94 g (17.4 mmol, corresponding to 33% of theory) of the product is obtained.

1. concentrationfinally concentrated by evaporation
2. customThe remaining residue is purified by chromatography (hexane/ethyl acetate: 3:1 plus 1% triethylamine)
3. custom4.94 g (17.4 mmol, corresponding to 33% of theory) of the product is obtained