反应详情

A mixture of 5.45 g of 3-bromo-2-pyridine carboxylic acid (27.0 mmol, 1 eq.), obtained in example 3b), in 100 ml of methanol is reflux heated in the presence of 8 ml of sulfuric acid. The reaction mixture is allowed to return to ambient temperature and poured into water. It is extracted 3 times with ethyl acetate, the organic phase is dried on Na2SO4 and vacuum evaporated. 2.48 g (42%) of esterified product is obtained.

1. temperatureis reflux
2. customto return to ambient temperature
3. extractionIt is extracted 3 times with ethyl acetate
4. customthe organic phase is dried on Na2SO4 and vacuum
5. customevaporated