Methanesulfonyl chloride → HCID 69219450, compound

HRID 272676Notes

Reaction equation

HRID 272676 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10]3[CH:12]=[C:13]([Cl:16])[CH:14]=[CH:15][C:9]=3[C:8](=[O:17])[NH:7][C:6]=2[CH:18]=1.[CH3:19][S:20](Cl)(=[O:22])=[O:21]>N1C=CC=CC=1>[Cl:16][C:13]1[CH:14]=[CH:15][C:9]2[C:8](=[O:17])[NH:7][C:6]3[CH:18]=[C:2]([NH:1][S:20]([CH3:19])(=[O:22])=[O:21])[CH:3]=[CH:4][C:5]=3[NH:11][C:10]=2[CH:12]=1

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 69217462HCID 69217462, compound

Product 1

HCID 69219450HCID 69219450, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of Example 7C (30 mg, 0.11 mmol) and CH3SO2Cl (13 mg, 0.112 mmol) in pyridine (4 mL) was stirred overnight at room temperature. The excess pyridine was removed under reduced pressure and the residue was washed with hexanes and filtered. The filter cake was dried in a vacuum oven to provide the desired product. MS (DCI) m/e 338 (M+H)+, 355 (M+NH4)+.

Workup

  1. customThe excess pyridine was removed under reduced pressure
  2. washthe residue was washed with hexanes
  3. filtrationfiltered
  4. customThe filter cake was dried in a vacuum oven

Sources & evidence

ORD record
ord-e0b9cdcc1e0a413d85f1c4c4c5e04074
Source dataset
uspto-grants-2008_11
Patent number
US07456169B2

Reaction notes

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