2-Cyanobenzenesulfonyl Chloride → HCID 69109528, compound

HRID 272788Notes

Reaction equation

HRID 272788 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9]([Cl:12])(=[O:11])=[O:10])#[N:2].[F:13][C:14]1([F:20])[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>>[ClH:12].[F:13][C:14]1([F:20])[CH2:19][CH2:18][N:17]([S:9]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[CH2:1][NH2:2])(=[O:11])=[O:10])[CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 5223472-Cyanobenzenesulfonyl ChlorideHCID 27583524,4-Difluoropiperidine

Product 1

HCID 69109528HCID 69109528, compoundYield 24.9%

Procedure

(2-(4,4-Difluoropiperidin-1-ylsulfonyl)phenyl)methanamine hydrochloride (81 mg) was prepared in two steps from commercially available 2-cyanobenzene-1-sulfonyl chloride (201 mg) and 4,4-difluoropiperidine (316 mg) in 25% overall yield following a procedure analogous to that used in the preparation 210A. LC-MS: 291.19 (M+H)+.

Workup

  1. customoverall yield

Sources & evidence

ORD record
ord-e5b7d88b2cc04c6b9990e5ce6b4a2b66
Source dataset
uspto-grants-2008_11
Patent number
US07456195B2

Reaction notes

Loading…