HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-3-chloropropane → 4-(3-Chloro-propyl)-thiomorpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-3-chloropropane | HCID 8006 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Thiomorpholine | HCID 67164 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 4-(3-Chloro-propyl)-thiomorpholine | HCID 23091686 | 96.5% |
Reaction Steps
Thiomorpholine (5 g, 49 mmol), acetone (15 ml, 3 vol), 5M NaOH solution (11.8 ml) and 1-bromo-3-chloropropane (11.6 g, 73.5 mmol, 1.5 eq.) were reacted together according to general procedure A to give the title compound (8.5 g, 96%) as a pale yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07456164B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-0de879639380460ab571aaaf6ace88de |
| Source note | uspto-grants-2008_11 |