1-Bromo-3-chloropropane → HCID 23091662, compound

HRID 272823Notes

Reaction equation

HRID 272823 reaction equation
[CH3:1][O:2][CH:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.[OH-].[Na+].Br[CH2:12][CH2:13][CH2:14][Cl:15]>CC(C)=O>[Cl:15][CH2:14][CH2:13][CH2:12][N:6]1[CH2:7][CH2:8][CH:3]([O:2][CH3:1])[CH2:4][CH2:5]1

Participants

5

Reactant 3

HCID 80061-Bromo-3-chloropropaneHCID 14798Sodium HydroxideHCID 776664-Methoxypiperidine

Product 1

HCID 23091662HCID 23091662, compoundYield 60.2%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

4-Methoxy-piperidine (1.5 g, 13 mmol), acetone (30 ml, 20 vol), 5M NaOH solution (3.13 ml) and 1-bromo-3-chloropropane (6.14 g, 39 mmol, 3 eq.) were reacted together according to general procedure A to give the title compound (1.5 g, 60%) as a pale yellow oil.

Sources & evidence

ORD record
ord-e641f9b5f22046d6bb2a756038ecdfde
Source dataset
uspto-grants-2008_11
Patent number
US07456164B2

Reaction notes

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