1-Bromo-3-chloropropane → HCID 61287133, compound

HRID 272835Notes

Reaction equation

HRID 272835 reaction equation
[CH2:1]([NH:3][CH2:4][CH2:5][OH:6])[CH3:2].[OH-].[Na+].Br[CH2:10][CH2:11][CH2:12][Cl:13]>CC(C)=O>[Cl:13][CH2:12][CH2:11][CH2:10][N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][OH:6]

Participants

5

Reactant 3

HCID 80061-Bromo-3-chloropropaneHCID 80722-(Ethylamino)ethanolHCID 14798Sodium Hydroxide

Product 1

HCID 61287133HCID 61287133, compoundYield 39%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

2-Ethylamino ethanol (6.2 g, 70 mmol), acetone (18 ml, 3 vol), 5M NaOH solution (16.8 ml, 1.2 eq.) and 1-bromo-3-chloropropane (16.5 g, 105 mmol, 1.5 eq.) were reacted together according to general procedure A to give the title compound (4.5 g, 39%) as a colourless oil.

Sources & evidence

ORD record
ord-2d723543138e40ac8213b95ada117971
Source dataset
uspto-grants-2008_11
Patent number
US07456164B2

Reaction notes

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