HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 1-(3-Chloro-2-methyl-propyl)-pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 1-Bromo-3-chloro-2-methylpropane | HCID 95566 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 1-(3-Chloro-2-methyl-propyl)-pyrrolidine | HCID 22568263 | 58% |
Reaction Steps
Pyrrolidine (3.0 g, 42 mmol), acetone (60 ml), 5M NaOH solution (10 ml) and 1-bromo-3-chloro-2-methyl-propane (21.7 g, 0.13 mol) were reacted together according to general procedure A to give the title compound (3.9 g, 58%) as a pale yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07456164B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-a31f384f1cea44a5a0b7bc0905ed2a50 |
| Source note | uspto-grants-2008_11 |