Sodium Hydroxide → 1-(3-Chloro-2-methyl-propyl)-pyrrolidine

HRID 272840Notes

Reaction equation

HRID 272840 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[Na+].Br[CH2:9][CH:10]([CH3:13])[CH2:11][Cl:12]>CC(C)=O>[Cl:12][CH2:11][CH:10]([CH3:13])[CH2:9][N:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 31268PyrrolidineHCID 955661-Bromo-3-chloro-2-methylpropane

Product 1

HCID 225682631-(3-Chloro-2-methyl-propyl)-pyrrolidineYield 58%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Pyrrolidine (3.0 g, 42 mmol), acetone (60 ml), 5M NaOH solution (10 ml) and 1-bromo-3-chloro-2-methyl-propane (21.7 g, 0.13 mol) were reacted together according to general procedure A to give the title compound (3.9 g, 58%) as a pale yellow oil.

Sources & evidence

ORD record
ord-a31f384f1cea44a5a0b7bc0905ed2a50
Source dataset
uspto-grants-2008_11
Patent number
US07456164B2

Reaction notes

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