反应详情

1-Cyclopentyl-4-hydroxypiperidine (1 g, 5.91 mmol), DCM (10 ml) and triethylamine (0.91 ml, 6.5 mmol) were cooled to 0-5° C. and mesyl chloride (0.46 ml, 5.91 mmol) was added dropwise under N2. The reaction was allowed to warm to room temperature and stirred for 1 hour. The reaction was quenched with sat. NaHCO3 (20 ml) and the aqueous phase extracted with DCM (2×5 ml). The combined organic extracts were dried over MgSO4, filtered, washed with DCM and concentrated in vacuo to give the title compound (1.38 g, 95%) as a pale yellow oil.

1. customThe reaction was quenched with sat. NaHCO3 (20 ml)
2. extractionthe aqueous phase extracted with DCM (2×5 ml)
3. dry with materialThe combined organic extracts were dried over MgSO4
4. filtrationfiltered
5. washwashed with DCM
6. concentrationconcentrated in vacuo