HCID 11667281, compound → HCID 68578749, compound

HRID 272974Notes

Reaction equation

HRID 272974 reaction equation
[CH:1]1([N:5]2[CH2:10][CH2:9][CH:8]([O:11][C:12]3[CH:17]=[CH:16][C:15]([C:18]4([C:24]#[N:25])[CH2:23][CH2:22][O:21][CH2:20][CH2:19]4)=[CH:14][CH:13]=3)[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH:1]1([N:5]2[CH2:10][CH2:9][CH:8]([O:11][C:12]3[CH:17]=[CH:16][C:15]([C:18]4([CH2:24][NH2:25])[CH2:19][CH2:20][O:21][CH2:22][CH2:23]4)=[CH:14][CH:13]=3)[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 11667281HCID 11667281, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 68578749HCID 68578749, compoundYield 100%

Procedure

The title compound (1.05 g, 100%) was prepared from 4-{4-[(1-cyclobutyl-4-piperidinyl)oxy]phenyl}tetrahydro-2H-pyran-4-carbonitrile and lithium aluminium hydride similarly to the procedure used for intermediate 51. LRMS APCI+ m/z 345 [MH]+.

Sources & evidence

ORD record
ord-cb295fd4a0fa46f596ac049a06dddd89
Source dataset
uspto-grants-2008_11
Patent number
US07456164B2

Reaction notes

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