HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → [4-(4-Methoxyphenyl)oxan-4-yl]-morpholin-4-ylmethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 4-(4-Methoxyphenyl)oxane-4-carboxylic acid | HCID 969802 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Product | [4-(4-Methoxyphenyl)oxan-4-yl]-morpholin-4-ylmethanone | HCID 976657 | 87% |
Reaction Steps
The title compound (3.1 g, 87%) was prepared using 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carboxylic acid, morpholine and O-(1H-benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (TBTU) similarly to the procedure used for example 166. HRMS ESI+ m/z 306.1696 [MH]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07456164B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-ed734d9725584c6894d57c16d92cb304 |
| Source note | uspto-grants-2008_11 |