[4-(4-Methoxyphenyl)oxan-4-yl]-morpholin-4-ylmethanone → 4-{[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methyl}-morpholine

HRID 273006Notes

Reaction equation

HRID 273006 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:15]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=O)[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([CH2:15][N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 976657[4-(4-Methoxyphenyl)oxan-4-yl]-morpholin-4-ylmethanoneHCID 21226445Aluminium lithium hydride

Product 1

HCID 685755274-{[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methyl}-morpholineYield 87%

Procedure

The title compound (2.48 g, 87%) was prepared using 4-{[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]carbonyl}morpholine and lithium aluminium hydride similarly to the procedure used for example 142. HRMS ESI+ m/z 292.1897 [MH]+.

Sources & evidence

ORD record
ord-706cc26355d041189cc3dc50b2b1dcc2
Source dataset
uspto-grants-2008_11
Patent number
US07456164B2

Reaction notes

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