反应详情

A solution of 4.2 g of trans-1-chloro-3-(3-ethyl-1-methylcyclobutyl)-prop-1-en-3-one (prepared in Example 5A) and 10 g of anhydrous sodium iodide in 60 ml of acetone was refluxed with about 0.5 ml H2SO4 for 4 hr under an argon atmosphere. The solvent was removed by evaporation in vacuo. The residue was diluted with water and the aqueous mixture was extracted several times with ether. The combined ether extract was washed with aqueous sodium thiosulfate solution and then dried over anhydrous magnesium sulfate and evaporated in vacuo to yield 6.8 g of the title compound having the following physical characteristics:

1. customThe solvent was removed by evaporation in vacuo
2. additionThe residue was diluted with water
3. extractionthe aqueous mixture was extracted several times with ether
4. extractionThe combined ether extract
5. washwas washed with aqueous sodium thiosulfate solution
6. dry with materialdried over anhydrous magnesium sulfate
7. customevaporated in vacuo