HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminium lithium hydride → 1-(4-{4-[(3-pyrrolidin-1-ylpropyl)thio]phenyl}tetrahydro-2H-pyran-4-yl)methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | 4-{4-[(3-pyrrolidin-1-ylpropyl)thio]phenyl}tetrahydro-2H-pyran-4-carbonitrile | HCID 59837485 | — |
| Product | 1-(4-{4-[(3-pyrrolidin-1-ylpropyl)thio]phenyl}tetrahydro-2H-pyran-4-yl)methanamine | HCID 68576679 | 91% |
Reaction Steps
The title compound (2.42 g, 91%) was prepared using 4-{4-[(3-pyrrolidin-1-ylpropyl)thio]phenyl}tetrahydro-2H-pyran-4-carbonitrile and lithium aluminium hydride similarly to the procedure used for intermediate 51. LRMS APCI+ m/z 335 [MH]+. Microanalysis: Found: C, 64.08; H, 8.79; N, 7.447%. C19H30N2OS.0.33DCM requires C, 64.04; H, 8.52; N, 7.73%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07456164B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-418bee775bcd453192c1d3040ae4dd4d |
| Source note | uspto-grants-2008_11 |