Pyrrolidine → HCID 68578404, compound

HRID 273014Notes

Reaction equation

HRID 273014 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][S:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3([C:22](O)=[O:23])[CH2:21][CH2:20][O:19][CH2:18][CH2:17]3)=[CH:12][CH:11]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1>>[N:25]1([C:22]([C:16]2([C:13]3[CH:12]=[CH:11][C:10]([S:9][CH2:8][CH2:7][CH2:6][N:1]4[CH2:2][CH2:3][CH2:4][CH2:5]4)=[CH:15][CH:14]=3)[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)=[O:23])[CH2:29][CH2:28][CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 68575836HCID 68575836, compound

Product 1

HCID 68578404HCID 68578404, compoundYield 40%

Procedure

The title compound (228 mg, 40%) was prepared using 4-{4-[(3-pyrrolidin-1-ylpropyl)thio]phenyl}tetrahydro-2H-pyran-4-carboxylic acid and pyrrolidine similarly to the procedure used for example 149.

Sources & evidence

ORD record
ord-f276b2b3673340dc88a0f77a5952fb1d
Source dataset
uspto-grants-2008_11
Patent number
US07456164B2

Reaction notes

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