Piperidin-4-ol → HCID 68576312, compound

HRID 273016Notes

Reaction equation

HRID 273016 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3([C:22]([OH:24])=O)[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]3)=[CH:12][CH:11]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[OH:25][CH:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[N:1]1([CH2:6][CH2:7][CH2:8][O:9][C:10]2[CH:11]=[CH:12][C:13]([C:16]3([C:22]([N:29]4[CH2:30][CH2:31][CH:26]([OH:25])[CH2:27][CH2:28]4)=[O:24])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]3)=[CH:14][CH:15]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 68576048HCID 68576048, compound

Product 1

HCID 68576312HCID 68576312, compoundYield 16%

Procedure

The title compound (200 mg, 16%) was prepared using 1-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]cyclohexanecarboxylic acid and 4-hydroxypiperidine similarly to the procedure used for example 149. HRMS ESI+ m/z 415.2943 [MH]+.

Sources & evidence

ORD record
ord-ab31f3e008f843ad8ab19246514e0ac0
Source dataset
uspto-grants-2008_11
Patent number
US07456164B2

Reaction notes

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