Piperazine → HCID 68578753, compound

HRID 273019Notes

Reaction equation

HRID 273019 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3([C:22](O)=[O:23])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]3)=[CH:12][CH:11]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[N:1]1([CH2:6][CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3([C:22]([N:25]4[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]4)=[O:23])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]3)=[CH:12][CH:11]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 68576048HCID 68576048, compound

Product 1

HCID 68578753HCID 68578753, compoundYield 19%

Procedure

The title compound (351 mg, 19%) was prepared using 1-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]cyclohexanecarboxylic acid and piperazine similarly to the procedure used for example 149. LRMS APCI+ m/z 400 [MH]+.

Sources & evidence

ORD record
ord-d73e5b0c8b724ccc891f94460ea4cd78
Source dataset
uspto-grants-2008_11
Patent number
US07456164B2

Reaction notes

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