HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → Tert-butyl 4-cyano-4-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | N-BOC-N,N-Bis(2-chloroethyl)amine | HCID 11230235 | — |
| Reactant | [4-(3-Pyrrolidin-1-ylpropoxy)phenyl]acetonitrile | HCID 23091635 | — |
| Product | Tert-butyl 4-cyano-4-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]piperidine-1-carboxylate | HCID 68578770 | 53% |
Reaction Steps
The title compound (1.8 g, 53%) was prepared using [4-(3-pyrrolidin-1-ylpropoxy)phenyl]acetonitrile, tert-butyl bis(2-chloroethyl)carbamate, sodium hydride and potassium iodide similarly to the procedure used for intermediate 56. LRMS APCI+ m/z 414 [MH]+ and m/z 245 [SMH]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07456164B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-99a15bfc9377498b88ae6c26e02a8a5c |
| Source note | uspto-grants-2008_11 |