HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonyl chloride → 4-(7-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-3-isoquinolinyl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | (2R)-(-)-2-Methylpyrrolidine hydrochloride | HCID 11147704 | — |
| Reactant | 4-[7-(2-Hydroxyethyl)-3-isoquinolinyl]benzonitrile | HCID 67104667 | — |
| Product | 4-(7-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-3-isoquinolinyl)benzonitrile | HCID 25197094 | — |
Reaction Steps
The product from Example 74B, methanesulfonyl chloride, and (2R)-2-methylpyrrolidine hydrochloride are processed as described in Example 62F to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07456196B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-119e707a75bd4dac83d0d7834b5faa2d |
| Source note | uspto-grants-2008_11 |