Methanesulfonyl chloride → 4-(7-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-3-isoquinolinyl)benzonitrile

HRID 273234Notes

Reaction equation

HRID 273234 reaction equation
O[CH2:2][CH2:3][C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[C:9]([C:14]3[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][CH:15]=3)[N:10]=[CH:11]2)=[CH:6][CH:5]=1.CS(Cl)(=O)=O.Cl.[CH3:28][C@@H:29]1[CH2:33][CH2:32][CH2:31][NH:30]1>>[CH3:28][C@@H:29]1[CH2:33][CH2:32][CH2:31][N:30]1[CH2:2][CH2:3][C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[C:9]([C:14]3[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][CH:15]=3)[N:10]=[CH:11]2)=[CH:6][CH:5]=1

Participants

4

Reactant 3

HCID 31297Methanesulfonyl chlorideHCID 11147704(2R)-(-)-2-Methylpyrrolidine hydrochlorideHCID 671046674-[7-(2-Hydroxyethyl)-3-isoquinolinyl]benzonitrile

Product 1

HCID 251970944-(7-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-3-isoquinolinyl)benzonitrile

Procedure

The product from Example 74B, methanesulfonyl chloride, and (2R)-2-methylpyrrolidine hydrochloride are processed as described in Example 62F to provide the title compound.

Sources & evidence

ORD record
ord-119e707a75bd4dac83d0d7834b5faa2d
Source dataset
uspto-grants-2008_11
Patent number
US07456196B2

Reaction notes

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