反应详情

A mixture of 3.99 g (16 mmol) of 1′H-[2,2′;6′,2″]terpyridin-4′-one (L1) and 8.0 g (38 mmol) of phosphorus pentachloride is boiled at reflux in 200 ml of phosphorus oxychloride for sixteen hours. The mixture is allowed to cool and concentrated to dryness. 200 ml of ice-water are then added cautiously to the residue, and the solution is then adjusted to pH 9 with aqueous potassium hydroxide solution. Extraction is carried out three times using chloroform and the organic extracts are dried over sodium sulfate, filtered and concentrated. After recrystallisation from ethanol, 4′-chloro-[2,2′;6′,2″]terpyridine is obtained in the form of white needles.

1. temperatureto cool
2. concentrationconcentrated to dryness
3. addition200 ml of ice-water are then added cautiously to the residue
4. extractionExtraction
5. dry with materialthe organic extracts are dried over sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated
8. customAfter recrystallisation from ethanol