反应详情

A mixture of 4-methoxy-2-aminopyridine (1.07 g, 8.6 mmol) and ethyl 2-chloroacetoacetate (5.4 g) in EtOH (50 mL) was refluxed for 24 h. The reaction mixture was then concentrated to half its volume, extracted with CH2Cl2, washed with brine and then water, and dried over anhydrous MgSO4. The solvent was removed in vacuo and the residue was purified on a silica gel column eluting with EtOAc and then MeOH/CH2Cl2 (1:9) to give ethyl 7-methoxy-2-methylimidazo[1,2-a]pyridine-3-carboxylate (2.71 g, 90%).

1. temperaturewas refluxed for 24 h
2. concentrationThe reaction mixture was then concentrated to half its volume
3. extractionextracted with CH2Cl2
4. washwashed with brine
5. dry with materialwater, and dried over anhydrous MgSO4
6. customThe solvent was removed in vacuo
7. customthe residue was purified on a silica gel column
8. washeluting with EtOAc