反应详情

4-Methoxy-2-methylpyridine (0.123 g, 1 mmol) and bromoacetone (0.16 mL, 1 mmol) were heated at 95° C. under N2 for 2 h. 1,8-Diazabicyclo-[5.4.0]-undec-7-ene (0.34 mL, 2.2 mmol) in benzene (10 mL) was added. The mixture was then refluxed under N2 for 1 h, poured into ice water, and then extracted with EtOAc. The combined organic layers were washed with water and dried. After the solvent was removed in vacuo, the residue was purified on a silica gel column eluting with EtOAc:Hexane (1:9) and EtOAc to give 7-methoxy-2-methylindolizine (0.050 g, 31%).

1. temperatureThe mixture was then refluxed under N2 for 1 h
2. extractionextracted with EtOAc
3. washThe combined organic layers were washed with water
4. customdried
5. customAfter the solvent was removed in vacuo
6. customthe residue was purified on a silica gel column
7. washeluting with EtOAc:Hexane (1:9) and EtOAc