反应详情

A mixture of 6-methoxybenzofuran-3-carbaldehyde (0.600 g, 3.41 mmol), HOCH2CH2OH (3.17 g, 51 mmol) and p-toluenesulfonic acids (0.001 g) in benzene (20 mL) was refluxed for 8 h using a Dean-Stark water trap. The mixture was concentrated under reduced pressure and then diluted with EtOAc. The organic solution was washed with water, dried over anhydrous MgSO4, and concentrated to give 3-(1,3-dioxolan-2-yl)-6-methoxybenzofuran (0.711 g, 95%)

1. temperaturewas refluxed for 8 h
2. concentrationThe mixture was concentrated under reduced pressure
3. additiondiluted with EtOAc
4. washThe organic solution was washed with water
5. dry with materialdried over anhydrous MgSO4
6. concentrationconcentrated