Sodium Hydroxide → 2-ethoxy-3-(4-{2-[2-(pentafluoroethyl)-1H-benzimidazol-1-yl]ethoxy}phenyl)propanoic acid

HRID 273361Notes

Reaction equation

HRID 273361 reaction equation
[CH2:1]([O:3][CH:4]([CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][N:20]2[C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=3[N:22]=[C:21]2[C:29]([F:35])([F:34])[C:30]([F:33])([F:32])[F:31])=[CH:13][CH:12]=1)[C:5]([O:7]CC)=[O:6])[CH3:2].[OH-].[Na+]>C(O)C.O>[CH2:1]([O:3][CH:4]([CH2:10][C:11]1[CH:12]=[CH:13][C:14]([O:17][CH2:18][CH2:19][N:20]2[C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=3[N:22]=[C:21]2[C:29]([F:34])([F:35])[C:30]([F:33])([F:31])[F:32])=[CH:15][CH:16]=1)[C:5]([OH:7])=[O:6])[CH3:2]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 86609608ethyl 2-ethoxy-3-(4-{2-[2-(pentafluoroethyl)-1H-benzimidazol-1 yl]ethoxy}phenyl)propanoate

Product 1

HCID 118519042-ethoxy-3-(4-{2-[2-(pentafluoroethyl)-1H-benzimidazol-1-yl]ethoxy}phenyl)propanoic acid

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

The ethyl ester (200 mg, 0.4 mmol) from Step B was hydrolysed using NaOH (64 mg, 1.6 mmol) in ethanol (10 ml) and water (5 ml) by the procedure described in Step C of Example 1 (141 mg, 75%).

Sources & evidence

ORD record
ord-becb569356f44c90926f7409f5195d07
Source dataset
uspto-grants-2008_11
Patent number
US07456293B2

Reaction notes

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