Triethylamine → HCID 86609609, compound

HRID 273364Notes

Reaction equation

HRID 273364 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[N:7]([CH2:8][CH2:9][OH:10])[C:6]2[CH:11]=[CH:12][C:13]([C:15]([F:18])([F:17])[F:16])=[CH:14][C:5]=2[N:4]=1.CCN(CC)CC.[CH3:28][S:29](Cl)(=[O:31])=[O:30]>C(Cl)Cl>[CH3:28][S:29]([O:10][CH2:9][CH2:8][N:7]1[C:6]2[CH:11]=[CH:12][C:13]([C:15]([F:18])([F:17])[F:16])=[CH:14][C:5]=2[N:4]=[C:3]1[C:2]([F:1])([F:19])[F:20])(=[O:31])=[O:30]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 83423578HCID 83423578, compound

Product 1

HCID 86609609HCID 86609609, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

To a stirred solution of 2-[2,5-bis(trifluoromethyl)-1H-benzimidazol-1-yl]ethanol (5.36 g, 17 mmol) in CH2Cl2 (15 ml), Et3N (5.0 ml, 36 mmol) was added and cooled to 0° C. To the cooled solution, methanesulfonyl chloride (1.53 ml, 19.8 mmol) was added slowly.

Sources & evidence

ORD record
ord-010a1a6d478546518fa2e41864d44549
Source dataset
uspto-grants-2008_11
Patent number
US07456293B2

Reaction notes

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