HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen chloride-ethyl acetate → HCID 69316376, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Reactant | HCID 58903100 | HCID 58903100 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 69316376 | HCID 69316376 | 71% |
Reaction Steps
To a solution of 3-[4-({2′,6′-dimethyl-4′-[3-(6-methylpyridin-2-yl)propoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid (55 mg, 0.11 mmol) in ethyl acetate (2.2 mL) was added 4 N hydrogen chloride-ethyl acetate solution (81 μL, 0.32 mmol) and the mixture was concentrated under reduced pressure. The obtained crystals were collected by filtration, washed and dried to give the title compound (42 mg, yield 71%) as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07456218B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-8b1e23642cf14fea9d4ae9cd7a19537b |
| Source note | uspto-grants-2008_11 |