Hydrogen chloride-ethyl acetate → HCID 69316376, compound

HRID 273411Notes

Reaction equation

HRID 273411 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH3:18])[N:13]=2)[CH:5]=[C:4]([CH3:19])[C:3]=1[C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH2:26][O:27][C:28]2[CH:33]=[CH:32][C:31]([CH2:34][CH2:35][C:36]([OH:38])=[O:37])=[CH:30][CH:29]=2)[CH:21]=1.C(OCC)(=O)C.[ClH:45]>C(OCC)(=O)C>[ClH:45].[CH3:19][C:4]1[CH:5]=[C:6]([O:8][CH2:9][CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH3:18])[N:13]=2)[CH:7]=[C:2]([CH3:1])[C:3]=1[C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH2:26][O:27][C:28]2[CH:33]=[CH:32][C:31]([CH2:34][CH2:35][C:36]([OH:38])=[O:37])=[CH:30][CH:29]=2)[CH:21]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 58903100HCID 58903100, compound

Product 1

HCID 69316376HCID 69316376, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 3-[4-({2′,6′-dimethyl-4′-[3-(6-methylpyridin-2-yl)propoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid (55 mg, 0.11 mmol) in ethyl acetate (2.2 mL) was added 4 N hydrogen chloride-ethyl acetate solution (81 μL, 0.32 mmol) and the mixture was concentrated under reduced pressure. The obtained crystals were collected by filtration, washed and dried to give the title compound (42 mg, yield 71%) as colorless crystals.

Workup

  1. concentrationthe mixture was concentrated under reduced pressure
  2. filtrationThe obtained crystals were collected by filtration
  3. washwashed
  4. customdried

Sources & evidence

ORD record
ord-8b1e23642cf14fea9d4ae9cd7a19537b
Source dataset
uspto-grants-2008_11
Patent number
US07456218B2

Reaction notes

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