反应详情

温度

60 °C

1,5-Diazabicyclo[5,4,0]-undec-5-ene (6 ml) is added to a solution of nitromethane (91.5 g) in methanol (500 ml). The resulting mixture is heated to 60° C. and methyl crotonate (100 g, lm) is added under nitrogen. The mixture is then stirred for 6 days at 60° after which it is cooled to room temperature and most of the methanol is removed in vacuo. The residue is treated with ether (500 ml) and washed with 2 N hydrochloric acid (250 ml) and water (250 ml). The organic layer is dried (Na2SO4) and evaporated in vacuo to give crude product. The crude product is purified by column chromatography on silica gel (500 g, ethyl acetate/hexane 2:98) to give methyl 3-methyl-4-nitrobutanoate (106.6 g, 66%).

1. customis removed in vacuo
2. additionThe residue is treated with ether (500 ml)
3. washwashed with 2 N hydrochloric acid (250 ml) and water (250 ml)
4. dry with materialThe organic layer is dried (Na2SO4)
5. customevaporated in vacuo
6. customto give crude product
7. customThe crude product is purified by column chromatography on silica gel (500 g, ethyl acetate/hexane 2:98)