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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 273565Generated: October 25, 2026

2-(Bromomethyl)pyridine → 5-(4-chlorophenyl)-N-(4-piperazin-1-ylphenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamide

https://huagongshe.com/reaction/273565

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Bromomethyl)pyridineHCID 564209—
Reactantt-Butyl 4-(4-(5-(4-chlorophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylateHCID 168301698—
ReagentSulfuric AcidHCID 1118—
Reagenttert-Butylimino-tri(pyrrolidino)phosphoraneHCID 3856267—
SolventDimethylformamideHCID 6228—
SolventDiglymeHCID 8150—
Product5-(4-chlorophenyl)-N-(4-piperazin-1-ylphenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamideHCID 53475321123%
Productt-Butyl 4-(4-(5-(4-chlorophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylateHCID 168301698—

Reaction Conditions

Temperature23 °C

Provenance & Evidence

DOI10.1038/s44160-023-00351-1
Source datasetCernak miniaturized N-alkylation with BOC deprotection
ORD IDord-1f26af956a71434e9f62fabcf331d04e
Source noteCernak miniaturized N-alkylation with BOC deprotection