4-Piperidinecarboxylic acid → 1-Acetylpiperidine-4-carboxylic acid

HRID 273688Notes

Reaction equation

HRID 273688 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]([OH:9])=[O:8])[CH2:3][CH2:2]1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>>[C:10]([N:1]1[CH2:6][CH2:5][CH:4]([C:7]([OH:9])=[O:8])[CH2:3][CH2:2]1)(=[O:12])[CH3:11]

Participants

3

Reactant 2

HCID 37734-Piperidinecarboxylic acidHCID 7918Acetic Anhydride

Product 1

HCID 1172551-Acetylpiperidine-4-carboxylic acid

Procedure

1-Acetylpiperidine-4-carboxylic acid is prepared by bringing a solution of piperidine-4-carboxylic acid in acetic anhydride to reflux for 2 hours and then stirring for 16 hours at room temperature. The solution is then concentrated and the residue is triturated in ether. The solid compound is recovered by filtration.

Workup

  1. temperatureto reflux for 2 hours
  2. concentrationThe solution is then concentrated
  3. customthe residue is triturated in ether
  4. filtrationThe solid compound is recovered by filtration

Sources & evidence

ORD record
ord-90f4bb99ebd4472094cdb311170e5dc3
Source dataset
uspto-grants-1995_02
Patent number
US05387586

Reaction notes

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