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HRID273693

反应详情

EQUATION

反应方程式

HRID 273693 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OO
HCID6410

tert-Butyl hydroperoxide

C4H10O2

结构：CC(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@H]3[C@@H]4CC[C@H](OC(C)=O)[C@@]4(C)CC[C@@H]32)C1
HCID102205

Androstenediol 3,17-diacetate

C23H34O4

PRODUCTS

生成物

1
结构：CC(=O)O[C@H]1CC[C@@]2(C)C(=CC(=O)[C@H]3[C@@H]4CC[C@H](OC(C)=O)[C@@]4(C)CC[C@@H]32)C1
HCID9886600

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[Cr]
催化剂HCID25589

未命名化合物

PROCEDURE

实验过程

A second method of preparing βAET has been developed which also used 3β,17β diacetoxyandrost-5-ene as a starting material as before. This compound was oxidized with t-butylhydroperoxide in the presence of chromium hexacarbonyl (Cr(CO)6) to form 3β,17β-diacetoxyandrost-5-en-7-one as described by Pearson [Pearson, et al., J. Chem Soc. Perkin Trans. I, 267 (1985)]. The enone formed then was reduced with triisobutylaluminum (TIBA) to give the acetylated 7β-hydroxy (I) product.

WORKUP

后处理

  1. customA second method of preparing βAET