Sodium Hydroxide → HCID 16660877, compound

HRID 273697Notes

Reaction equation

HRID 273697 reaction equation
Br[C@@H:2]1[CH2:7][C@H:6]2[C@H:8]3[C@H:18]([CH2:19][CH2:20][C@:4]2([CH3:5])[C@H:3]1[OH:23])[C@:16]1([CH3:17])[C:11]([CH2:12][C@@H:13]([OH:21])[CH2:14][CH2:15]1)=[CH:10][C@@H:9]3[OH:22].[OH-:24].[Na+]>CN(C)C=O>[OH:21][C@H:13]1[CH2:14][CH2:15][C@@:16]2([CH3:17])[C:11](=[CH:10][C@H:9]([OH:22])[C@@H:8]3[C@@H:18]2[CH2:19][CH2:20][C@@:4]2([CH3:5])[C@H:6]3[CH2:7][C@@H:2]([OH:24])[C@@H:3]2[OH:23])[CH2:12]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 15231377HCID 15231377, compound

Product 1

HCID 16660877HCID 16660877, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

16α-bromo-3β,7β,17β-trihydroxyandrost-5-ene (CLIII, X=Br) is reacted with sodium hydroxide in dimethylformamide to form 3β,7β,16α,17β-tetrahydroxyandrost-5-ene (CLXI)

Sources & evidence

ORD record
ord-f0380915aefc42ce8859461679dce404
Source dataset
uspto-grants-1995_02
Patent number
US05387583

Reaction notes

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