Methanesulfonic Acid → 4H-Pyrido(1,2-a)pyrimidine-3-carboxamide, 6-methyl-4-oxo-N-propyl-, methanesulfonate (1:1)

HRID 273723Notes

Reaction equation

HRID 273723 reaction equation
[CH2:1]([NH:4][C:5]([C:7]1[C:12](=[O:13])[N:11]2[C:14]([CH3:18])=[CH:15][CH:16]=[CH:17][C:10]2=[N:9][CH:8]=1)=[O:6])[CH2:2][CH3:3].[CH3:19][S:20]([OH:23])(=[O:22])=[O:21]>>[CH3:19][S:20]([OH:23])(=[O:22])=[O:21].[CH2:1]([NH:4][C:5]([C:7]1[C:12](=[O:13])[N:11]2[C:14]([CH3:18])=[CH:15][CH:16]=[CH:17][C:10]2=[N:9][CH:8]=1)=[O:6])[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 6395Methanesulfonic AcidHCID 30792734H-Pyrido(1,2-a)pyrimidine-3-carboxamide, 6-methyl-4-oxo-N-propyl-

Product 1

HCID 30792984H-Pyrido(1,2-a)pyrimidine-3-carboxamide, 6-methyl-4-oxo-N-propyl-, methanesulfonate (1:1)

Procedure

After dissolving 1.527 g (0.00623 mol) of N-propyl-6-methyl-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxamide by heating, 0.61 ml (0.009 mol) of methanesulfonic acid is dropped to the clear yellow solution. On cooling, 1.84 g (86.8%) of the named salt are precipitated as a white crystalline substance, m.p.: 183°-185° C.

Workup

  1. temperatureby heating
  2. temperatureOn cooling
  3. custom1.84 g (86.8%) of the named salt are precipitated as a white crystalline substance, m.p.: 183°-185° C.

Sources & evidence

ORD record
ord-60970109a5d24085a36fb5a8584b44bd
Source dataset
uspto-grants-1995_02
Patent number
US05387588

Reaction notes

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