Lawesson's reagent → HCID 20094125, compound

HRID 273790Notes

Reaction equation

HRID 273790 reaction equation
O=[C:2]1[C:8]2[S:9][CH:10]=[CH:11][C:7]=2[N:6]2[CH:12]=[N:13][C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:5]2[CH2:4][NH:3]1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:29])=CC=1>C1(C)C=CC=CC=1>[S:29]=[C:2]1[C:8]2[S:9][CH:10]=[CH:11][C:7]=2[N:6]2[CH:12]=[N:13][C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:5]2[CH2:4][NH:3]1

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 20094163HCID 20094163, compound

Product 1

HCID 20094125HCID 20094125, compoundYield 132.1%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

4. 24.07 g of ethyl 5,6-dihydro-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylate are suspended in 260 ml of toluene and treated with 22.73 g of Lawesson reagent. The mixture is heated to reflux temperature for 1.25 h., then cooled and filtered. The filter cake is dried. 21.78 g of ethyl 5,6-dihydro-6-thioxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylate are obtained.

Workup

  1. temperatureThe mixture is heated
  2. temperatureto reflux temperature for 1.25 h.
  3. temperaturecooled
  4. filtrationfiltered
  5. customThe filter cake is dried

Sources & evidence

ORD record
ord-1258d2b56b1b4c4e8a961a38253cb02a
Source dataset
uspto-grants-1995_02
Patent number
US05387585

Reaction notes

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