Ammonia → HCID 20094043, compound

HRID 273801Notes

Reaction equation

HRID 273801 reaction equation
[Br:1][C:2]1[C:3]2[C:4]3[N:5]([CH:12]=[CH:13][N:14]=3)C=[N:7][C:8]=2[CH:9]=[CH:10][CH:11]=1.N>Cl>[Br:1][C:2]1[C:3]([C:4]2[NH:14][CH:13]=[CH:12][N:5]=2)=[C:8]([CH:9]=[CH:10][CH:11]=1)[NH2:7]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 20093923HCID 20093923, compound

Product 1

HCID 20094043HCID 20094043, compoundYield 88.5%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

5. 11.6 g of 10-bromoimidazo[1,2-c]quinazoline are stirred in 170 ml of 6N hydrochloric acid at 90° C. for 6.5 h. and then cooled in an ice bath. The reaction solution is poured into 30 ml of 25% aqueous ammonia and 50 g of ice and stirred for 10 min. The crystals are filtered off, washed with water and dried in a vacuum. 9.85 g of 3-bromo-2-(1H-2-imidazolyl)-aniline are obtained. The aqueous phase is saturated with sodium chloride and extracted three times with chloroform. After evaporation of the organic extracts in a vacuum, there are obtained a further 1.52g of 3-bromo-2-(1H-2-imidazolyl)-aniline. The substance can be recrystallized from water. M.p. 164°-165° C.

Workup

  1. temperaturecooled in an ice bath
  2. filtrationThe crystals are filtered off
  3. washwashed with water
  4. customdried in a vacuum

Sources & evidence

ORD record
ord-f68d1cdb3f0147a1a474063c6d8a833d
Source dataset
uspto-grants-1995_02
Patent number
US05387585

Reaction notes

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