Sodium Hydroxide → HCID 23712930, compound

HRID 273867Notes

Reaction equation

HRID 273867 reaction equation
[CH2:1]([O:3][C:4]1[CH:36]=[CH:35][CH:34]=[CH:33][C:5]=1[O:6][CH2:7][CH2:8][NH:9][CH:10]([CH3:32])[CH2:11][C:12]1[CH:13]=[C:14]2[C:18](=[C:19]([C:21](=[O:23])[NH2:22])[CH:20]=1)[N:17]([CH2:24][CH2:25][CH2:26][C:27]([O:29]CC)=[O:28])[CH2:16][CH2:15]2)[CH3:2].[OH-].[Na+:38]>C(O)C>[CH2:1]([O:3][C:4]1[CH:36]=[CH:35][CH:34]=[CH:33][C:5]=1[O:6][CH2:7][CH2:8][NH:9][CH:10]([CH3:32])[CH2:11][C:12]1[CH:13]=[C:14]2[C:18](=[C:19]([C:21](=[O:23])[NH2:22])[CH:20]=1)[N:17]([CH2:24][CH2:25][CH2:26][C:27]([O-:29])=[O:28])[CH2:16][CH2:15]2)[CH3:2].[Na+:38]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 20094372HCID 20094372, compound

Product 1

HCID 23712930HCID 23712930, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of ethyl 4-[5-[2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-7-carbamoylindolin-1-yl]butyrate (88 mg) in ethanol (1 ml) was added a 1N aqueous sodium hydroxide solution (180 μl), and the mixture was stirred at room temperature for 6 hours. The reaction mixture was purified by medium pressure liquid column chromatography on ODS using a mixture of methanol and water (1/1) as eluent to give 51 mg of sodium 4-[5-[2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-7-carbamoylindolin-1-yl]butyrate as an oil.

Workup

  1. customThe reaction mixture was purified by medium pressure liquid column chromatography on ODS
  2. additiona mixture of methanol and water (1/1) as eluent

Sources & evidence

ORD record
ord-33370d74f94643868dd92f55b279db8a
Source dataset
uspto-grants-1995_02
Patent number
US05387603

Reaction notes

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