Sodium Hydroxide → HCID 23712930, compound

Participants

Reaction Steps

To a solution of ethyl 4-[5-[2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-7-carbamoylindolin-1-yl]butyrate (88 mg) in ethanol (1 ml) was added a 1N aqueous sodium hydroxide solution (180 μl), and the mixture was stirred at room temperature for 6 hours. The reaction mixture was purified by medium pressure liquid column chromatography on ODS using a mixture of methanol and water (1/1) as eluent to give 51 mg of sodium 4-[5-[2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-7-carbamoylindolin-1-yl]butyrate as an oil.

Provenance & Evidence