6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride → alpha-(3,4-Dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-gamma-methyl-alpha-[(4-methylphenyl)thio]-2(1H)-isoquino linepentanenitrile

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride	HCID 6456035	—
Edukt	HCID 19042099	HCID 19042099	—
Produkt	alpha-(3,4-Dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-gamma-methyl-alpha-[(4-methylphenyl)thio]-2(1H)-isoquino linepentanenitrile	HCID 20094567	17.563,4%

Reaktionsschritte

The procedure of Example 2 is repeated using 4.0 g of α-(3-chloro-2-methylpropyl)-3,4-dimethoxy-α-[(4-methylphenyl)thio]benzeneacetonitrile and 3.5 g of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride. This affords 0,985 g of the desired product as a yellow foam.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US05387685
Quelldatensatz	uspto-grants-1995_02
ORD ID	ord-77e0ce66614b4cff85a6c75c9625f1b0
Quellennotiz	uspto-grants-1995_02