Acetic Anhydride → HCID 20094860, compound

HRID 274052Notes

Reaction equation

HRID 274052 reaction equation
[CH2:1]([NH:8][CH:9]1[CH2:15][CH2:14][CH2:13][C:12]2[CH:16]=[CH:17][C:18]([N+:20]([O-:22])=[O:21])=[CH:19][C:11]=2[CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:23](OC(=O)C)(=[O:25])C.C(=O)([O-])O.[Na+]>C(O)=O>[CH2:1]([N:8]([CH:23]=[O:25])[CH:9]1[CH2:15][CH2:14][CH2:13][C:12]2[CH:16]=[CH:17][C:18]([N+:20]([O-:22])=[O:21])=[CH:19][C:11]=2[CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 516892Sodium BicarbonateHCID 18007288HCID 18007288, compound

Product 1

HCID 20094860HCID 20094860, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A mixture of N-benzyl-3-nitro-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-amine (2.8 g), formic acid (8 ml) and acetic anhydride (16 ml) was stirred at ambient temperature for 15 hours. The reaction mixture was poured into an aqueous solution of sodium hydrogen carbonate, and extracted twice with ethyl acetate. The extract was dried over anhydrous sodium sulfate and concentrated in vacuo to give N-benzyl-N-formyl-3-nitro-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-amine (2.71 g).

Workup

  1. extractionextracted twice with ethyl acetate
  2. dry with materialThe extract was dried over anhydrous sodium sulfate
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-9efc1f38c0c64a5088ccc8fd390a0b4c
Source dataset
uspto-grants-1995_02
Patent number
US05387710

Reaction notes

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