Hydrogen Bromide → HCID 20094770, compound

HRID 274092Notes

Reaction equation

HRID 274092 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]([NH:12]C(OC)=O)[CH2:6]2.[BrH:17]>>[BrH:17].[OH:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]([NH2:12])[CH2:6]2

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 20094757HCID 20094757, compound

Product 1

HCID 20094770HCID 20094770, compound

Procedure

A mixture of 5-methoxy-N-methoxycarbonylindan-2-amine (0.25 g) and 47% hydrobromic acid (20 ml) was refluxed for 4 hours. After cooling, the mixture was concentrated in vacuo. Toluene was added to the residue and the whole was concentrated in vacuo to dryness to give 5-hydroxyindan-2-amine hydrobromide (0.26 g).

Workup

  1. temperaturewas refluxed for 4 hours
  2. temperatureAfter cooling
  3. concentrationthe mixture was concentrated in vacuo
  4. additionToluene was added to the residue
  5. concentrationthe whole was concentrated in vacuo to dryness

Sources & evidence

ORD record
ord-751b2f6f07f54e88bd944d091fbc32c4
Source dataset
uspto-grants-1995_02
Patent number
US05387710

Reaction notes

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