反应详情

温度

110 °C

5.07 g (0,03 mol) of 1-(tetrahydro-2-oxo-3-furyl)-2-pyrrolidinone are mixed with 10.45 g (0.12 mol) of morpholine and the reaction mixture is heated at 110° C. for 5 hours. Upon cooling, the product crystallizes. The product is filtered and recrystallized from diethyl ether. 6.3 g (yield: 82% of theory) of 4-[4-hydroxy-2-(2-oxo-1-pyrrolidinyl)butyryl]-morpholine are obtained. M.P.: 105°-106° C.

1. temperatureUpon cooling
2. customthe product crystallizes
3. filtrationThe product is filtered
4. customrecrystallized from diethyl ether