Morpholine → HCID 23342866, compound

HRID 27410Notes

Reaction equation

HRID 27410 reaction equation
[O:1]=[C:2]1[CH:6]([N:7]2[CH2:11][CH2:10][CH2:9][C:8]2=[O:12])[CH2:5][CH2:4][O:3]1.[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>>[OH:3][CH2:4][CH2:5][CH:6]([N:7]1[CH2:11][CH2:10][CH2:9][C:8]1=[O:12])[C:2]([N:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1)=[O:1]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 23342878HCID 23342878, compound

Product 1

HCID 23342866HCID 23342866, compoundYield 82%

Conditions

Temperature
110 °C

Procedure

5.07 g (0,03 mol) of 1-(tetrahydro-2-oxo-3-furyl)-2-pyrrolidinone are mixed with 10.45 g (0.12 mol) of morpholine and the reaction mixture is heated at 110° C. for 5 hours. Upon cooling, the product crystallizes. The product is filtered and recrystallized from diethyl ether. 6.3 g (yield: 82% of theory) of 4-[4-hydroxy-2-(2-oxo-1-pyrrolidinyl)butyryl]-morpholine are obtained. M.P.: 105°-106° C.

Workup

  1. temperatureUpon cooling
  2. customthe product crystallizes
  3. filtrationThe product is filtered
  4. customrecrystallized from diethyl ether

Sources & evidence

ORD record
ord-998d1067ea0c4e829ca7f57386e40294
Source dataset
uspto-grants-1980_09
Patent number
US04221789

Reaction notes

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